Risk of hepatocellular carcinoma in hepatitis B and D virus co?infected patients: A systematic review and meta?analysis of longitudinal studies
نویسندگان
چکیده
Hepatitis D virus (HDV) infection causes a severe chronic viral hepatitis with accelerated development of liver cirrhosis and decompensation, but whether it further increases the risk hepatocellular carcinoma (HCC) is unclear. We performed comprehensive systematic review published literature meta-analysis to assess HCC in HDV B (HBV) co-infected, compared HBV mono-infected patients. The study was conducted per priori defined protocol, including only longitudinal studies, thus excluding cross-sectional studies. Random-effects models were used determine aggregate effect sizes (ES) 95% confidence intervals (CI). Meta-regression examine associations among level characteristics. Twelve cohort studies comprising total 6099 HBV/HDV co-infected 57,620 patients analysed. overall pooled ES showed that at 2-fold increased (ES = 2.12, CI 1.14–3.95, I2 72%, N 12). A six-fold significant noted HIV/HBV/HDV triple-infected, HIV/HBV magnitude did not differ significantly after adjustment for design quality, publication year follow-up duration univariable meta-regression analysis. This shows associated higher mono-infection. surveillance strategies taking this into account, new treatment options against HDV, are warranted.
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چکیده ندارد.
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ژورنال
عنوان ژورنال: Journal of Viral Hepatitis
سال: 2021
ISSN: ['1365-2893', '1352-0504']
DOI: https://doi.org/10.1111/jvh.13577